belindabgarana/dmea repository overview

Though there are many algorithms for drug repurposing, most only evaluate individual drugs which can be prone to off-target effects. In contrast, our approach is to evaluate drug mechanisms of action by aggregating results across many drugs. Though mechanisms of action have also been evaluated in a similar manner by the Connectivity Map (clue.io), Drugmonizome (https://maayanlab.cloud/drugmonizome⁠), and DrugEnrichr(https://maayanlab.cloud/DrugEnrichr⁠), these tools only allow analysis of select public datasets and do not consider the ranks or directionality of input features. With our tool Drug Mechanism Enrichment Analysis (DMEA), users can query any dataset of interest using either an input gene signature or drug rank list to identify enriched mechanisms of action for drug repurposing efforts. For more information, please visit our website: https://belindabgarana.github.io/DMEA⁠