dockerpjhuang/profun repository overview

ProFun: A web server for functional enrichment analysis of parasitic protozoan genes

Huang PJ, Weng YC, Huang KY, Lee CC, Yeh YM, Chen YT, Chiu CH, Tang P. ProFun: A web server for functional enrichment analysis of parasitic protozoan genes. J Microbiol Immunol Infect. 2024 Jun;57(3):509-517. doi: 10.1016/j.jmii.2024.01.007

ProFun is a web-based platform designed for functional enrichment analysis (FEA) of parasitic protozoans, addressing the lack of dedicated tools for these pathogens. While FEA is a crucial step in multi-omics studies, most existing tools focus on humans and model organisms.

Built with Docker, ShinyProxy, and R Shiny, ProFun provides a scalable and user-friendly interface. It includes three analytical modules—Gene Overlaps, Over-representation Analysis (ORA), and Gene Set Enrichment Analysis (GSEA)—for 40 protozoan species. Users can simply input a gene list, customize enrichment parameters, and generate publication-ready visualizations with a single click.

ProFun enables researchers to quickly interpret biological functions, identify potential targets, and compare FEA results across experimental designs. As the first tool of its kind, it accelerates multi-omics research on parasitic protozoans. ProFun is freely available at http://dalek.cgu.edu.tw:8080/app/profun⁠.