fhaive/totka repository overview

⁠📦 TOTKA Shiny Application

TOTKA is a comprehensive R-Shiny application for integrated AOP‑anchored framework that combines transcriptomic dose-response modeling with physiologically based kinetic (PBK) simulation.

It integrates following core R packages into a single graphical interface, enabling streamlined physiologically based kinetic (PBK) simulation and adverse outcome pathway (AOP) mapping:

• PfasDosim package⁠
• AOPfingerprintR package⁠

⁠Source Code

The source code is available at the GitHub repository https://github.com/fhaive/totka⁠.

⁠Install Docker application

https://www.docker.com/products/docker-desktop/⁠

⁠Pull the TOTKA docker image:

docker pull --platform linux/amd64 fhaive/totka:latest

⁠Run the TOTKA docker image

map http port 80 on the host port 80:

docker run -p 80:80 totka:latest /bin/bash -c "cd /TOTKA/ && R -e \" options('shiny.port'=80,shiny.host='0.0.0.0');library(TOTKA);setwd('/TOTKA/');TOTKA::run_app() \""

⁠Using TOTKA:

Open your browser and visit: 127.0.0.1:80 (if you choose to map to other port replace 80 in the url with the correct one)

⁠Data for demo:

Sample data can be found at: https://github.com/fhaive/totka/sample_data/liver_spheroids/⁠

⁠📬 Contact

For questions, suggestions, or contributions, please contact [Angela Serra] at [[email protected]⁠].