labsyspharm/driadrc repository overview

⁠DRIADrc: full reproducibility of manuscript figures

This is a companion to Drug Repurposing In Alzheimer's Disease (DRIAD), a machine learning framework for quantifying potential associations between drugs and Alzheimer's Disease.

• Nature communications article: https://www.nature.com/articles/s41467-021-21330-0⁠
• Primary DRIAD repository: https://github.com/labsyspharm/DRIAD⁠
• DRIAD as a webapp: https://labsyspharm.shinyapps.io/DRIAD/⁠

⁠Reproducing the figures

All scripts and data needed to fully reproduce the figures are encapsulated inside a Docker container. Ensure that you have Docker installed⁠. Then run the following command:

docker run -v "$PWD":/output/ --rm labsyspharm/driadrc make

This will generate figures.pdf and supplement.pdf in your current directory.

⁠Funding

We gratefully acknowledge support by NIA grant R01 AG058063: Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimers Disease.