pascalpetit/dessypher repository overview

⁠DeSSyPHER – Decision Support System for the Prevention of Human Exposome-related Health Risks

DeSSyPHER is a repository of Dockerized Shiny applications designed to address the lack of standardized tools for assessing health risks associated with the human exposome. The repository currently provides several specialized applications:

• InCaRisk (Inhalation Cancer Risk estimation)

Goal: Assesses inhalation cancer risks following exposure to a single chemical using a lifetime approach.

Principal Investigators: Pascal Petit, Dominique J. Bicout

Publications:
-Petit P, Maître A, Bicout DJ. A consensus approach for estimating health risk: application to inhalation cancer risks. Environ Res. 2021;196:110436. DOI⁠
-Petit P, Maître A, Bicout DJ. InCaRisk: Application web interactive pour l'estimation des risques de cancer par inhalation. TIMC e-Mag, Lettre n°20, Mai 2021. [in French]
-Petit P, Bicout DJ. Health risk assessment with multiple reference indices. Sci Total Environ. 2022;804:149971. DOI⁠

• PRéCI (Prévention des Risques de Cancer par Inhalation)

Goal: Educational French version of InCaRisk, for students, public health professionals, and occupational health practitioners.

Principal Investigators: Pascal Petit, Dominique J. Bicout

• PAH HBM Tool (Polycyclic Aromatic Hydrocarbon Human Biomonitoring)

Goal: Supports interpretation and decision-making for PAH mixture risk assessment based on 1-hydroxypyrene concentrations from human biomonitoring.

Principal Investigator: Pascal Petit
Collaborator: Renaud Persoons

Publication: Clauzel A, Persoons R, Maître A, Balducci F, Petit P. Review of environmental airborne pyrene/benzo[a]pyrene levels for improving 1-hydroxypyrene biomonitoring interpretation. J Toxicol Environ Health B Crit Rev. 2024;27(5-6):212-232. DOI⁠

• SurvBioHAP (Surveillance Biologique des HAP)

Educational French version of PAH HBM Tool, for students, practitioners, and public health professionals.

Principal Investigator: Pascal Petit
Collaborator: Renaud Persoons

• TEDI (Toxicological and Exposure Database Inventory)

Goal: Provides a comprehensive inventory of toxicological and exposure data sources for chemical exposome risk assessment.

Principal Investigator: Pascal Petit
Collaborator: Dominique J. Bicout

Publication: Petit P. Toxicological and Exposure Database Inventory. Int J Hyg Environ Health. 2022;246:114055. DOI⁠

⁠User Guide (Docker-based apps)

⁠Prerequisites

• Docker installed (https://www.docker.com/get-started⁠)
• Docker running in the background
• Internet connection to pull Docker images

⁠Option 1 – Using the launcher executable (.exe, .sh, .command)

Windows

1. Download the launcher executable (e.g., InCaRisk.exe) from GitHub (https://github.com/PetitPascal/DeSSyPHER/tree/main⁠).
2. Double-click the .exe.
   • The launcher automatically pulls the latest Docker image, runs the Shiny app container, and opens your default web browser.

Linux / Mac

1. Download the .sh (Linux) or .command (Mac) launcher file.
2. Open a terminal, navigate to the folder containing the launcher, and run:

# Linux
chmod +x InCaRisk_launcher.sh
./InCaRisk_launcher.sh

# Mac
chmod +x InCaRisk_launcher.command
./InCaRisk_launcher.command

⁠Option 2 – Running Docker images directly via PowerShell / Terminal

Windows (PowerShell)

# Pull the latest image
docker pull pascalpetit/dessypher:incarisk_v4.0

# Run the container, mapping host port 3840 to container port 3838
docker run --rm -d -p 3840:3838 pascalpetit/dessypher:incarisk_v4.0

# Open the app in the default web browser
Start-Process "http://localhost:3840"

Linux / Mac (Terminal)

# Pull the latest image
docker pull pascalpetit/dessypher:incarisk_v4.0

# Run the container, mapping host port 3840 to container port 3838
docker run --rm -d -p 3840:3838 pascalpetit/dessypher:incarisk_v4.0

# Open the app in the default web browser
xdg-open http://localhost:3840  # Linux
open http://localhost:3840      # Mac

Notes:

• Each app runs in its own Docker container and may use a different host port.
• Multiple apps can run simultaneously in separate browser tabs.
• Launchers automatically update the Docker image when executed.