vipinsurendran13/v13shield repository overview

⁠V13Shield

V13Shield is an open-source pharmacogenomics (PGx) screening tool designed to rapidly identify inherited genetic variants associated with high risks of severe chemotherapy toxicity directly from standard Variant Call Format (VCF) files.

The tool screens clinically actionable pharmacogenes (DPYD, TPMT, NUDT15, UGT1A1) against curated CPIC guidelines and translates raw molecular data into an interactive HTML dashboard containing clear toxicological warnings and automated data visualizations.

⁠Source code: https://github.com/vipinsurendran13/v13shield⁠

⁠How to Run It

⁠1. Using Docker (Local Machine)

To run the tool against your own local VCF data, mount your current working directory to the container:

docker run --rm \
  -v $(pwd):/data \
  vipinsurendran13/v13shield:latest \
  --input /data/patient.vcf \
  --outdir /data/results \
  --json