yinxiu/variantalker repository overview

Variant annotation in cancer genomics involves identifying and characterizing the genetic changes (variants) that contribute to cancer development and progression. The challenge is that there are many different types of variants that can occur in the genome, and not all of them are relevant to cancer. Therefore, accurate annotation is critical for identifying the key driver mutations and designing targeted therapies. However, this process is complicated by the large number of potential variants, the need to integrate data from multiple sources, and the ongoing discovery of new cancer-associated variants.

The docker contains the resources needed to run the Nextflow pipeline called variantalker (https://github.com/zhanyinx/variantalker⁠) that enables users to annotate variants from VCF files. Our pipeline supports VCF files generated from dragen, nf-sarek, and ION-torrent platforms.